método para produção de (r)-1,1,3-trimetil-4-aminoindano

• Main Authors: TADAFUMI MATSUNAGA, MASAYA TANIMOTO, TOMOHIKO INUI, NATSURU HIRAGURI, TOMOAKI TAKAHASHI
• Format: Patent
• Language: Portuguese
• Published: 19.01.2021
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; APPARATUS THEREFOR; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

método para produção de (r)-1,1,3-trimetil-4-aminoindano. é fornecido um método para produção de (r)-1,1,3-trimetil-4-aminoindano, o método incluindo as seguintes etapas (a), (b), e (c). (a): uma etapa de oticamente resolver o 1,1,3-trimetil-4-aminoindano a fim de obter (r)-1,1,3-trimetil-4-aminoindano e (s)-1,1,3-trimetil-4-ami-noindano. (b): uma etapa de racemizar o (s)-1,1,3-trimetil-4-amino-indano obtido na etapa (a) ou na etapa (c) a fim de obter 1,1,3-trimetil-4-aminoindano. (c): uma etapa de oticamente resolver o 1,1,3-trimetil-4-aminoindano obtido na etapa (b) a fim de obter (r)-1,1,3-trimetil-4-aminoindano e (s)-1,1,3-trimetil-4-aminoindano. A method for producing (R)-1,1,3-trimethyl-4-aminoindane includes the following steps (A), (B), and (C). Step (A) is a step of optically resolving 1,1,3-trimethyl-4-aminoindane to obtain (R)-1,1,3-trimethyl-4-aminoindane and (S)-1,1,3-trimethyl-4-aminoindane, step (B) is a step of racemizing the (S)-1,1,3-trimethyl-4-aminoindane obtained in the step (A) or (C) to obtain 1,1,3-trimethyl-4-aminoindane, and step (C) is a step of optically resolving the 1,1,3-trimethyl-4-aminoindane obtained in the step (B) to obtain (R)-1,1,3-trimethyl-4-aminoindane and (S)-1,1,3-trimethyl-4-aminoindane.