compostos inibidores da aminopirimidina quinase

• Main Authors: CARMEN M. BALDINO, JUSTIN L. CASERTA, STEPHANE A. DUMAS, YVONNE L. FLANDERS, CHEE-SENG LEE
• Format: Patent
• Language: Portuguese
• Published: 12.01.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

inibidores da aminopirimidina quinase. a presente invenção refere-se a compostos de aminopirimidina, composições farmacêuticas contendo esses compostos, e usos dos compostos e composições como moduladores de ck1, ck1v1, ck1v2, ck1v3, ck2, pim1, pim2, pim3, a via de tgfß, a via de wnt, a via de jak/stat, a via de akt, e/ou a via de mtor. também são divulgados os usos para o tratamento ou prevenção de uma série de indicações terapêuticas devido, pelo menos em parte, à atividade fisiológica aberrante de ck1, ck1v1, ck1v2, ck1v3, ck2, pim1, pim2, pim3, a via de tgfß, a via de wnt, a via de jak/stat, a via de akt, e/ou a via de mtor. 21160244v1 1/1 21160244v1 Disclosed are compounds, pharmaceutical compositions containing those compounds, and uses of the compounds and compositions as modulators of CK1, CK1γ1, CK1γ2, CK1γ3, CK2, Pim 1, Pim2, Pim3, the TGFβ pathway, the Wnt pathway, the JAK/STAT pathway, the AKT pathway, and/or the mTOR pathway. Uses are also disclosed for the treatment or prevention of a range of therapeutic indications due at least in part to aberrant physiological activity of CK1, CK1γ1, CK1γ2, CK1γ3, CK2, Pim 1, Pim2, Pim3, the TGFβ pathway, the Wnt pathway, the JAK/STAT pathway, the AKT pathway, and/or the mTOR pathway.