derivados de piperidinona como inibidores mdm2 para o tratamento de câncer

• Main Authors: JIANG ZHU, YOSUP REW, ZHIHONG LI, JOEL MCINTOSH, BRIAN MATTHEW FOX, DAVID JOHN KOPECKY, JONATHAN DANTE LOW, STEVEN HOWARD OLSON, JIWEN LIU, LAWRENCE MCGEE, BENJAMIN FISHER, FRANK KAYSER, DUSTIN MCMINN, JIASHENG FU, HILARY PLAKE BECK, JULIO CESAR MEDINA, ZIAOQI CHEN, JULIE ANNE HEATH, MING YU, MICHAEL WILLIAM GRIBBLE JR, MICHAEL JOHNSON, ZHIHUA MA, XIN HUANG, YINGCAI WANG, SUJEN LAI, MICHAEL DAVID BARTBERGER, XIAODONG WANG, XUELEI YAN, FELIX GONZALEZ LOPEZ DE TURISO, JASON DUQUETE, BRIAN STUART LUCAS, JEFFREY DEIGNAN, RICHARD VICTOR CONNORS, DAQING SUN, JOHN EKSTEROWICZ, ANA GONZALEZ BUENROSTRO, YIHONG LI, JEFFREY THOMAS MIHALIC, PHILIP MARLEY ROVETO, DARIN JAMES GUSTIN, XIANYUN JIAO, ZICE FU
• Format: Patent
• Language: Portuguese
• Published: 08.11.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides MDM2 inhibitor compounds of Formula IE,which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.