Formas sólidas de (r)-1-(2,2-difluorbenzo[d] [1,3] dioxol-5-il)-n-(1-(2,3-diidroxipropil)-6-flúor-2-(1-hidróxi-2-metilpropan-2-il)-1h-indol-5-il)ciclopropanocarboxamida, composições farmacêuticas e dispersões sólidas compreendendo as mesmas, 5 processo de preparação e usos das mesmas, e kit compreendendo as mesmas

• Main Authors: Keshavarz-Shokri Ali, Zhang Beil, Tim Edward Alcacio, Krawiec Mariusz, Elaine Chungmin Lee, Zhang Yuegang
• Format: Patent
• Language: Portuguese
• Published: 28.09.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

formas sólidas de (r)-1-(2,2-difluorbenzo[d][1,3]dioxol-5-il)-n-(1-(2,3-diidroxipropil)-6-flúor-2-(1-hidróxi-2-metilpropan-2-il)-1h-indol-5-il) ciclopropanocarboxamida, composições farmacêuticas e dispersões sólidas compreendendo as mesmas, processo de preparação e usos das mesmas, e kit compreendendo as mesmas. a presente invenção se refere às formas sólidas de (r)-1-(2,2-diflúorbenzo[d][1,3]dioxol-5-il)-n-(1-(2,3-diidroxipropil)-6-flúor-2-(1-hidróxi-2-metilpropan-2-il)-1h-indol-5-il)ciclopropanocarboxamida (composto 1) na forma substancialmente cristalina (forma a) ou forma amorfa, composições farmacêuticas das mesmas e usos das mesmas. The present invention relates to solid forms of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1) in substantially crystalline form (Form A) or amorphous form, pharmaceutical compositions thereof, and methods of treatment therewith.