Composições e métodos para a terapia e diagnóstico de câncer de mama

• Main Authors: CRAIG H. DAY, DAVIN C. DILLON, STEVEN G. REED, LYNDA E. MISHER, YASIR A. W. SKEIKY, MARC W. RETTER, SUSAN L. HARLOCKER, JOHN M. SMITH, TONY N. FRUDAKIS, AIJUN WANG
• Format: Patent
• Language: Portuguese
• Published: 22.06.2004
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

"COMPOSIçõES E MéTODOS PARA A TERAPIA E DIAGNóSTICO DE CâNCER DE MAMA". Trata-se de composições e métodos para a terapia e diagnóstico de câncer, particularmente câncer de mama, são descritos. Composições ilustrativas compreendem um ou mais polipeptídeos do tumor da mama, porções imunogênicas destes, polinucleotídeos que codificam tais polipeptídeos, célula apresentando antígeno que expressa tais polipeptídeos, e células T que são específicas para as células expressarem tais polipeptídeos. As composições descritas são úteis, por exemplo, no diagnóstico, prevenção e/ou tratamento de doenças, particularmente câncer da mama. Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.