processo para preparação de derivados spiro-[cis-4-(b-hidroxietiloxi) ciclohexano-[3h] indol]-2' [1'h]-ona

The invention relates to a process for the preparation of spiro[cis-4-(beta-hydroxyethyloxy)cyclohexane-[3H]indol]-2'[1'H]-one derivatives of the formula (I) wherein R1 and R2 are as defined herein, by reduction of a dispiro[(1,3-dioxolane)-2,4'-cyclohexane-1'3'-[3H]indol]-2...

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Bibliographic Details
Main Authors GERGELY HEJA, LAJOS NAGY, ANDREA SANTANE CSUTOR, ISTVAN HERMECZ, KALMAN SIMON, FELIX HAJDU, JUDIT HALASZ, LASZLO KIS, TIBORNE SZOMOR, EVA CSIKOS, GYOERGYNE SZVOBODA, CSABA GOENCZI
Format Patent
LanguagePortuguese
Published 17.05.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a process for the preparation of spiro[cis-4-(beta-hydroxyethyloxy)cyclohexane-[3H]indol]-2'[1'H]-one derivatives of the formula (I) wherein R1 and R2 are as defined herein, by reduction of a dispiro[(1,3-dioxolane)-2,4'-cyclohexane-1'3'-[3H]indol]-2''[1''H]-one derivative of general formula (II), wherein R1 and R2 are as defined herein, which comprises carrying out the reduction (a) with sodium cyanoborohydride in the presence of a Lewis acid, or (b) with sodium borohydride in the presence of a strong acid.
Bibliography:Application Number: BR20000012427