EPI - EPIBATYDINE DERIVATIVES

• Main Authors: BALOGH, ZSUZSANNA, GIGLER, GABOR, SIMIG, GYULA, CSOERGO, MARGIT, DRABANT, SANDOR, SZALLAST, TAMAS, GYERTYAN, ISTVAN, TEMESVARI, ESZTER, SZEMEREDI, KATALIN, FEKETE, MARTON, MANDI, ATTILA, LADY, BLANKA, SZANTAY, CSABA, LAX, GYOERGYI, BLASKO, GABOR, SOMOGYI, MARIA, MOLDVAI, ISTVAN
• Format: Patent
• Language: English
• Published: 29.09.1995
• Edition: 5
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to compounds having the general formula where R means lower alkyl, lower alkenyl, lower alkynyl, lower cycloalkyl, aryl, heteroaryl, aryl-lower alkyl or heteroaryl-lower alkyl, the indicated group, optionally, being substituted by one or more lower alkyl, lower alkenyl, lower alkynyl, low cycloalkyl, aryl, heteroaryl, aryl-lower alkyl, heteroaryl-lower alkyl, hydroxy, lower alkoxy, phenoxy, halogen, halogen-lower alkyl, amino-, mono- or disubstituted amono-, amido- and/or sulphonamide substituent(s); and R' meaning hydrogen, lower alkyl, lower alkenyl, lower alkynyl, lower cycloalkyl, lower cycloalkenyl, lower cycloalkynyl, aryl-lower alkyl, aryl, heteroaryl, halogeno-lower alkyl, hydroxy-lower alkyl or acyl; and their pharmaceutically acceptable acid adjunctive salts, having very strong analgetic effect. The compounds with tha above formula are new, provided that R is different from 6-chloro-3-pyridyl when R' is hydrogen.