NOVEL ACYLGUANADINE DERIVATIVES AS INHIBITORS OF BONE RESORPTION AND AS VITRONECTIN RECEPTOR ANTAGONISTS

• Main Authors: KNOLLE JOCHEN, MCDOWELL ROBERT, GADEK THOMAS, PEYMAN ANUSCHIRWAN, GOURVEST JEAN-FRANCOIS, BREIPOHL GERHARD, CARNIATO DENIS, SCHEUNEMANN KARL-HEINZ, FERRARA NAPOLEANE, BODARY SARAH, CUTHBERTSON ROBERT
• Format: Patent
• Language: Bulgarian; English
• Published: 28.02.2006
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Съединенията са антагонисти на витронектиновия рецептор и инхибитори на костната резорбция чрез остеокласти. Подходящи са за лечение или профилактикана заболявания, причинени поне частично от нежелан размер на костна резорбция, например остеопороза. Те имат формула в която R1, R2, R4, R5 и R6, A, m и n имат значенията, посочени в описанието. Изобретението се отнася също и до методи за получаванена посочените съединения и до тяхното приложение,по-специално като фармацевтично активни ингредиенти, и до фармацевтични продукти, които ги съдържат. The compounds are vitronectin receptor antagonists and inhibitors of bone resorption by osteoclasts. They are suitable for the therapy or prophylaxis of diseases which are caused at least partially by an undesired extend of bone resorption, for example of osteoporosis. The have the formula in which R1, R2, R4, R5 and R6, A, m and n have the meanings indicated in the description. The invention also relates to methods for the preparation of the said compounds and to their application, in particular as pharmaceutical active ingredients, and to pharmaceutical preparations comprising them.