PROCESS FOR PRODUCING OF CYCLIC PROPYLENE ESTER OF DIHYDROPYRIDINE-S-PHOSPHONIC ACID

• Main Authors: MASUDA, YUKINORI, SAKODA, RYOZO, SAKAI, TOSINORI, TANAKA, SAKUYA, SETO, KIYOTOMO
• Format: Patent
• Language: Bulgarian; English
• Published: 24.01.1994
• Edition: 5
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

Методът намира приложение за синтез на биологичноактивни вещества с изразен антихипертензивен и съдоразширяващ ефект. Те са с обща формула The process is used for the synthesis of biologically active substances of expressed antihypertensive and vasodilative effect. They are of the general formula: wherein each of R1 to R6 beingthe same equal or different, is hydrogen or methyl; one of the substitudes X1 and X2 is nitro or chloride, and the other - hydrogen or each of X1 and X2 is chlorine, Y is wherein A is -CH2CH2- or -CH(CH3)CH2-, and m is an integer of 1, 2 or 3 or Y is where A means -CH2CH2- or CH2CH2CH2 and A1, and stand for Ar2 phenyl or p-fluorphenyl, when X1 and X2 are chloaine pharmaceutically acceptable salt or solvate of the compound or of its salt. They are produced in reaction between a compound of a formula and compound of a formula