МЕТОД ЗА ПОЛУЧАВАНЕ НА ЦИКЛИЧЕН ПРОПИЛЕНОВ ЕСТЕР НА ДИХИДРОПИРИДИН-5-ФОСФОНОВА КИСЕЛИНА

• Main Authors: MASUDA, YUKINORI, SAKODA, RYOZO, SAKAI, TOSINORI, TANAKA, SAKUYA, SETO, KIYOTOMO
• Format: Patent
• Language: Bulgarian
• Published: 24.01.1994
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Методът намира приложение за синтез на биологично активни вещества с изразен антихипертензивен и съдоразширяващ ефект. Те са с обща формула A compound of the formula: wherein each of R , R , R , R , R and R which may be the same or different, is hydrogen or C1-C4 alkyl; one of X and X is nitro, fluorine, chlorine, difluoromethoxy or trifluoromethyl and the other is hydrogen, or both of X and X are chlorine; and Y is wherein A is C2-C6 alkylene, each of Ar and Ar which may be the same or different, is phenyl which may be substituted by chlorine, fluorine or C1-C3 alkoxy, and m is an integer of from 0 to 4, or Y is wherein A, Ar and Ar are as defined above when that both X and X are chlorine; or a pharmaceutically acceptable salt thereof, or a solvate of the compound or the salt.