CYCLIC AMINE DERIVATIVES AND THEIR USE AS DRUGS

A compound represented by general formula, a pharmaceutically acceptable acid addition salt thereof or a pharmaceutically acceptable C1-C6 alkyl addition salt thereof, and their metal applications. Since these compounds inhibit the action of chemokines such as MIP-1alpha and/or MCP-1on target cells,...

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Main Authors TEIG, STEVEN, TARBY, CHRISTINE M, IMAI, MINORU, SHIOTA, TATSUKI, TAKENOUCHI, OSAMI, FURUYA, MINORU, MUROGA, YUMICO, SUDOH, MASAKI, ENDO, NORIAKI, HADA, TAKAHIKO, MORITA, TAKUYA, KATAOKA, KEN-ICHIRO, TSUTSUMI, TAKAHARU, MOREE, WILNA, SOGAWA, RYO
Format Patent
LanguageBulgarian
English
Published 31.01.2001
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A compound represented by general formula, a pharmaceutically acceptable acid addition salt thereof or a pharmaceutically acceptable C1-C6 alkyl addition salt thereof, and their metal applications. Since these compounds inhibit the action of chemokines such as MIP-1alpha and/or MCP-1on target cells, they may be useful as a therapeutic drug and/or preventive drug in diseases, such as atherosclerosis, rheumatoid arthritis, and the like where blood monocytes and lymphocytes infiltrate into the tissues. 54 claims
Bibliography:Application Number: BG20000104441