Characterization of the gsk-3beta protein and methods of use thereof

The invention provides the three-dimensional structure of a construct of glycogen synthase kinase 3 (GSK3); crystals of a construct of glycogen synthase kinase 3-beta (GSK3-beta) containing the protein's catalytic kinase domain; a method for crystallizing the protein construct to provide a GSK3...

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Bibliographic Details
Main Authors MIN HE, JOHANNA M. JANSEN, ERIC MARTIN, VINCENT P. LE, S. MICHAEL CHIN, DIRKSEN E. BUSSIERE
Format Patent
LanguageEnglish
Published 02.04.2002
Edition7
Subjects
BEER
BIOCHEMISTRY
CALCULATING
CHEMISTRY
COMPOSITIONS THEREOF
COMPUTING
COUNTING
CULTURE MEDIA
ELECTRIC DIGITAL DATA PROCESSING
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
TESTING
VINEGAR
WINE
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Summary:The invention provides the three-dimensional structure of a construct of glycogen synthase kinase 3 (GSK3); crystals of a construct of glycogen synthase kinase 3-beta (GSK3-beta) containing the protein's catalytic kinase domain; a method for crystallizing the protein construct to provide a GSK3 crystal sufficient for structure determination; and a method for using the GSK3 construct's three-dimensional structure for the identification of possible therapeutic compounds in the treatment of various disease conditions mediated by GSK3 activity.
Bibliography:Application Number: AU19920090601