3-arylsulfonyl-2-hydroxy-2-methylpropanoic acid derivates

A compound which is an arylsulfonyl propanoic acid derivative of formula (I) : CH2R1 XC(O)-C(OH)-SO2-C6H4-N(R2)COA (I) wherein X is HO-NH- or HO- , R1 is selected from -O-Ph, -S-Ph, -S-Het, -Hyd or -CH2-Hyd, wherein Ph is a phenyl group; Het is a heterocyclic ring and Hyd is a substituted hydantoin-...

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Bibliographic Details
Main Authors SERGIO MANTEGANI, ETTORE PERRONE, FRANCESCA ABRATE, PAOLO CREMONESI, PIERLUIGI BISSOLINO
Format Patent
LanguageEnglish
Published 30.01.2002
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A compound which is an arylsulfonyl propanoic acid derivative of formula (I) : CH2R1 XC(O)-C(OH)-SO2-C6H4-N(R2)COA (I) wherein X is HO-NH- or HO- , R1 is selected from -O-Ph, -S-Ph, -S-Het, -Hyd or -CH2-Hyd, wherein Ph is a phenyl group; Het is a heterocyclic ring and Hyd is a substituted hydantoin-3-yl ring; A is a phenyl group or Het as defined above, or a condensed phenyl ring; and R2 is either hydrogen or methyl; or R2 represents a methylene (-CH2-) bridge connecting the N atom to the ortho position of said A to form a 5-membered lactam; or a salt or an oral prodrug thereof.The compounds are inhibitors of matrix metallo-proteinases (MMPs) and are therefore useful in the prevention, control and treatment of diseases in which MMPs are involved.
Bibliography:Application Number: AU19850080101