SULFONAMIDE DERIVATIVES

• Main Authors: NORIHIRO UEDA, KYOSUKI KITOH, HIROSHI YOSHINO, NOZOMU KOYANAGI, MAKOTO ASADA, TATSUO WATANABE, HIROYUKI SUGUMI, ATSUMI IIJIMA, TAKESHI NAGASU, KAPPEI TSUKAHARA, YOSHIHIKO KOTAKE, TOSHIMI OKADA, KENTARO YOSHIMATSU, JUN NIIJIMA
• Format: Patent
• Language: English
• Published: 27.02.1992
• Edition: 5
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; DERIVATIVES THEREOF; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

To provide new sulfonamide derivatives having an excellent antitumor activity and only a low toxicity and a process for producing them. Sulfonamide derivatives of the general formula (I): wherein preferably R represents a lower alkoxy group, R , R , R , R , R and R may be the same or different from one another and each represent a hydrogen atom, halogen atom or lower alkyl group, A and B may be the same or different from each other and each represent =N- or =CH-, E represents an aromatic 6-membered cyclic group (which may have 1 or 2 nitrogen atoms in the ring) which may be substituted with 1 to 3 substituents which may be the same or different from one another with the proviso that a combination of R which is a hydrogen atom, lower alkyl group, nitro group or amino group which may be protected, R and R which are each a hydrogen atom, A and B which are each =CH- and E which is a phenyl group which may be substituted with 1 to 3 substituents G which may be the same or different from one another is excluded, or pharmacologically acceptance salts of them.