Groes and groel homologs of francisella tularensis

• Main Authors: MARGARET GILLIAN HARTLEY, KERRI ANNE MACK, RICHARD WILLIAM TITBALL, ANDERS SJOSTEDT, MICHAEL GREEN
• Format: Patent
• Language: English
• Published: 13.03.2002
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

A polypeptide comprising at least one component of an Hsp60 obtainable from Francisella tularensis, and in particular the GroEL protein, or a fragment thereof, or a variant of any of these, which polypeptide, when administered to an animal, produces an immune response which is protective against F. tularensis infection, for use in prophylactic or therapeutic vaccination against F. tularensis. The polypeptide may be administered directly to the host, or nucleic acid encoding the polypeptide may be administered in a form in which they might be expressed in vivo. Vaccines based upon these polypeptides suitably include an additional component and in particular an adjuvant which promotes a cellular immune response.