Dihetero-substituted metalloprotease inhibitors

Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I): where J, M, Q, T, W, X, Z, R , R , R , R , R<4&#...

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Bibliographic Details
Main Authors MICHAEL GEORGE NATCHUS, MENYAN CHENG, NEIL GREGORY ALMSTEAD, BISWANATH DE, STANISLAW PIKUL
Format Patent
LanguageEnglish
Published 06.11.2003
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I): where J, M, Q, T, W, X, Z, R , R , R , R , R<4'>, R , R , R<6'>, R , m, and n have the meanings described in the specification. This invention also includes optical isomers, diastereomers and enantiomers of the formula above, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. Also disclosed are pharmaceutical compositions comprising these compounds, and methods of treating or preventing metalloprotease-related maladies using the compounds or the pharmaceutical compositions.
Bibliography:Application Number: AU3711800