Method for producing S-alkyl(aryl)-substituted imidazol derivatives

The invention relates to a process for the preparation of compounds of the formula (I)in which R(2) and R(3) independently of one another are -SR(4) or -COOR(5) and R(1), R(4) and R(5) have the meaning indicated in the description, which comprises cyclizing compounds of the formula IIin which R(1),...

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Bibliographic Details
Main Authors BERND NAPIERSKI, HEINZ-PETER REBENSTOCK, WOLFGANG HOLLA
Format Patent
LanguageEnglish
Published 07.08.2003
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a process for the preparation of compounds of the formula (I)in which R(2) and R(3) independently of one another are -SR(4) or -COOR(5) and R(1), R(4) and R(5) have the meaning indicated in the description, which comprises cyclizing compounds of the formula IIin which R(1), R(2) and R(3) have the meaning defined above, in the presence of alkylphosphonic anhydrides to give compounds of the formula (I), then purifying these in as is known per se by salt formation and, if appropriate, subsequent recrystallization and optionally removing radicals introduced for the protection of other functional groups in a manner known per se;and their use as intermediate for the synthesis of active compounds.
Bibliography:Application Number: AU19990026189