Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

Disclosed are compounds which inhibit beta -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta -amyloid peptide release and/or its synthesis as wel...

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Bibliographic Details
Main Authors THOMAS C. BRITTON, VARGHESE JOHN, RUSSELL D. STUCKY, JEFFREY S. NISSEN, STACEY L. MCDANIEL, MICHAEL A. PLEISS, JAMES E. AUDIA, BRUCE A. DRESSMAN, JAMES J. DROSTE, LEE H. LATIMER, STEVEN S. HENRY, JING WU, WILLIAM LEONARD SCOTT, CYNTHIA L. CWI, JAY S. TUNG, THOMAS E. MABRY, WARREN J. PORTER, JEFFREY NEITZ, STEPHEN FREEDMAN, EUGENE D. THORSETT, JON K. REEL
Format Patent
LanguageEnglish
Published 27.06.2002
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed are compounds which inhibit beta -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
Bibliography:Application Number: AU5700798