New carbapenem derivatives

• Main Authors: KAZUHIRO AIHARA, YUKO KANO, KATSUYOSHI IWAMATSU, KAZUKO KOBAYASHI, TAKASHI IDA, KUNIO ATSUMI, TOSHIRO SASAKI, YUMIKO TOYOOKA, HIROMASA TAKIZAWA, KENICHI FUSHIHARA
• Format: Patent
• Language: English
• Published: 22.03.2001
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The carbapenem derivatives represented by the following formula (I) is disclosed. These compounds have strong anti-bacterial activities against bacteria including methicillin resistant Staphylococcus aureus, penicillin resistant Streptococcus pneumoniae, Enterococci, influenza, and beta -lactamase producing bacteria, and have high stabilities to DHP-1. wherein R represents hydrogen or methyl, either one of R , R , R , or R represents the bond to the 2-position on the carbapenem ring, and the remaining three respectively represent hydrogen, halogen, nitro, cyano, alkyl, cycloalkyl, alkylthio, alkenyl, formyl, alkylcarbonyl, alkoxycarbonyl, aminosulfonyl, aryl carbonyl, aryl , carbamoyl, N-lower alkylcarbamoyl, N,N-di-lower alkylaminocarbonyl, lower alkoxyiminomethyl, or hydroxyiminomethyl, R is not present or represents alkyl, cycloalkyl, or alkenyl, and R is not present, or represents hydrogen or a group which may be metabolically hydrolyzed in the body, provided that when R is not present, R represents hydrogen or a group which may be metabolically hydrolyzed in the body, and when R is present, R is not present, and the compound forms an inner salt.