Improved process for the preparation of halo-4-phenoxyquinolines

The present invention relates to a new improved, simplified process for the preparation of halo-4-phenoxyquinolines, whereby thionyl chloride is used as the chlorinating agent to prepare the corresponding chloroquinoline intermediate prior to the final coupling reaction, and a single, inert high boi...

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Bibliographic Details
Main Authors JEFF T. BUDD, GARY A. ROTH, LARRY D. KERSHNER, JIMMY J. TAI, IAN R. KING, MARK A. HADD, TIM J. ADAWAY, JULIE L. MAURER, THOMAS A. OLMSTEAD, KARL L. KRUMEL
Format Patent
LanguageEnglish
Published 08.02.2001
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to a new improved, simplified process for the preparation of halo-4-phenoxyquinolines, whereby thionyl chloride is used as the chlorinating agent to prepare the corresponding chloroquinoline intermediate prior to the final coupling reaction, and a single, inert high boiling polyether solvent is used throughout the entire reaction procedure.
Bibliography:Application Number: AU19980059179