Dimer-selective RXR modulators and methods for their use

Dimer-selective RXR modulator compounds having agonist, partial agonist and/or antagonist activity in the context of an RXR homodimer and/or RXR heterodimers are provided. Also provided are pharmaceutical compositions incorporating such dimer-selective RXR modulator compounds and methods for their t...

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Main Authors BETH ANN BADEA, MARCUS F. BOEHM, LIN ZHANG, RANJAN MUKHERJEE, ALEX M. NADZAN, DEEPAK S. LALA, RICHARD A. HEYMAN, STACIE CANAN-KOCH, LAURA J. DARDASHTI, LUC J. FARMER, CHAN KOU HWANG
Format Patent
LanguageEnglish
Published 09.11.2000
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Dimer-selective RXR modulator compounds having agonist, partial agonist and/or antagonist activity in the context of an RXR homodimer and/or RXR heterodimers are provided. Also provided are pharmaceutical compositions incorporating such dimer-selective RXR modulator compounds and methods for their therapeutic use.
Bibliography:Application Number: AU19960073624