Amino-substituted thiadiazoles, pyrimidines, triazines or triazoles useful as CTF receptor antagonists

CRF receptor antagonists are disclosed. Such receptor antagonists are thiadiazole-, pyrimidine-, triazine-, and triazole-containing compounds substituted with both a C3-C14 monocyclic or fused, homoaryl or heteroaryl group and a substituted amine group. The CFR receptor antagonists have utility in t...

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Bibliographic Details
Main Authors ZHENGYU LIU, JAMES R. MCCARTHY, CHARLES Q. HUANG, DIMITRI E GRIGORIADIS, YUN FENG XIE, JOHN Y. RAMPHAL, THOMAS R WEBB, CHEN CHEN, JEFFREY P. WHITTEN, RAYMOND DAGNINO JR
Format Patent
LanguageEnglish
Published 23.03.2000
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:CRF receptor antagonists are disclosed. Such receptor antagonists are thiadiazole-, pyrimidine-, triazine-, and triazole-containing compounds substituted with both a C3-C14 monocyclic or fused, homoaryl or heteroaryl group and a substituted amine group. The CFR receptor antagonists have utility in the treatment of a variety of disorders, including disorders associated with the hypersecretion of CRF.
Bibliography:Application Number: AU19960059904