Derivatives of antibiotic GE2270 factors C2a D2 and E

PCT No. PCT/EP97/00628 Sec. 371 Date Jun. 29, 1998 Sec. 102(e) Date Jun. 29, 1998 PCT Filed Feb. 12, 1997 PCT Pub. No. WO97/30078 PCT Pub. Date Aug. 21, 1997Mono- or di-substituted derivatives of GE2270 factors C2a, D2 and E of general formula (I), wherein W represents a moiety of formula (a), (b) o...

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Main Authors ROMEO CIABATTI, ERMENEGILDO RESTELLI, SERGIO LOCIURO, PAOLO TAVECCHIA
Format Patent
LanguageEnglish
Published 13.01.2000
Edition6
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PCT No. PCT/EP97/00628 Sec. 371 Date Jun. 29, 1998 Sec. 102(e) Date Jun. 29, 1998 PCT Filed Feb. 12, 1997 PCT Pub. No. WO97/30078 PCT Pub. Date Aug. 21, 1997Mono- or di-substituted derivatives of GE2270 factors C2a, D2 and E of general formula (I), wherein W represents a moiety of formula (a), (b) or (c), R1 and R2 representing a variety of substituents, X1 is methyl, X2 is a -CH2-W1 moiety and X3 is methylamino or amino, or X1 is a -CH2-W1 moiety, X2 is methoxymethylene and X3 is methylamino, with the proviso that when X3 is amino, then W must be 2-(aminocarbonyl)-pyrrolidinyl; with the further proviso that when W is 2-(aminocarbonyl)-pyrrolidinyl, then W1 cannot be hydroxy; and the pharmaceutically acceptable salts thereof. The mono- or di-substituted derivatives of antibiotic GE 2270 of formula (I) are antimicrobial agents mainly active against gram positive bacteria.
Bibliography:Application Number: AU19970017687