Oligomer conjugates and their use

This invention contemplates an oligomer conjugate having an oligomer capable of binding to a nucleic acid or protein present in a bacteria, an oligomer uptake enhancer molecule and a spacer attached to the oligomer uptake enhancer molecule and the oligomer. This invention also contemplates enhancing...

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Bibliographic Details
Main Authors ROBERT E. KLEM, JONATHAN M DIVER, MORTEZA M VAGHEFI, JOANN L DILEANIS, TIMOTHY A RILEY
Format Patent
LanguageEnglish
Published 20.12.1994
Edition5
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SUGARS
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Summary:This invention contemplates an oligomer conjugate having an oligomer capable of binding to a nucleic acid or protein present in a bacteria, an oligomer uptake enhancer molecule and a spacer attached to the oligomer uptake enhancer molecule and the oligomer. This invention also contemplates enhancing the uptake of an oligomer into a bacterial cell by directly and indirectly attaching an oligomer uptake enhancer molecule to an oligomer to form an oligomer conjugate with enhanced uptake properties. These oligomer conjugates can be used to inhibit bacterial growth in vivo and in vitro.
Bibliography:Application Number: AU19940070197