Process for 2-substituted benzo{b}thiophene compounds and intermediates thereof

The present invention provides processes for preparing compounds of formula I wherein R is -H, OH, or OR , in which R is a hydroxy protecting group; and R is -H, -OH, or OR , in which R is a hydroxy protecting group, and for preparing compounds of formula VII wherein R is -H, -OH, or OR , in which R...

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Bibliographic Details
Main Authors ALAN D. PALKOWITZ, KENNETH J. THRASHER, DANIEL J. SALL, KENNETH L. HAUSER
Format Patent
LanguageEnglish
Published 03.12.1998
Edition6
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention provides processes for preparing compounds of formula I wherein R is -H, OH, or OR , in which R is a hydroxy protecting group; and R is -H, -OH, or OR , in which R is a hydroxy protecting group, and for preparing compounds of formula VII wherein R is -H, -OH, or OR , in which R is a hydroxy protecting group; R is -H, -OH, or OR , in which R is a hydroxy protecting group; R is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1-hexamethyleneimino; R is bromo, chloro, iodo, or an activating ester group; and n is 2 or 3. Also provided are processes for preparing compounds of formula VII in addition to intermediates of formula IX wherein R<1'> is -OH, or -OR , in which R is a hydroxy protecting group; and Z is bromo, iodo, triflate, or -B(OH)2.or p
Bibliography:Application Number: AU19960053261