Ubiquitin conjugating enzymes

The present invention relates to drug screening assays which provide a systematic and practical approach for the identification of candidate agents able to inhibit ubiquitin-mediated degradation of a cell-cycle regulatory protein, such as p53, p27, myc, fos, MAT alpha 2, or cyclins. The invention fu...

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Bibliographic Details
Main Authors JENO GYURIS, MARK ROLFE, GIULIO DRAETTA, GUILLAUME COTTAREL, JENS W ECKSTEIN
Format Patent
LanguageEnglish
Published 27.08.1998
Edition6
Subjects
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Summary:The present invention relates to drug screening assays which provide a systematic and practical approach for the identification of candidate agents able to inhibit ubiquitin-mediated degradation of a cell-cycle regulatory protein, such as p53, p27, myc, fos, MAT alpha 2, or cyclins. The invention further relates to novel ubiquitin-conjugating enzymes, and uses related thereto.
Bibliography:Application Number: AU19950018669