Formulations for delivery of osteogenic proteins

A composition is disclosed comprising a pharmaceutically acceptable admixture of an osteogenic protein; a porous particulate polymer matrix; an osteogenic protein-sequestering amount of blood clot; and a calcium sulfate hemihydrate-containing substance. Also disclosed are formulations of bone morpho...

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Bibliographic Details
Main Authors JOHN J. STECKERT, JAY A. SCHRIER, C. MICHAEL PHILBROOK, JENNIFER L. SMITH, RICHARD A. KENLEY, PATRICK JOSEPH DESOUZA, RICHARD P. NORTHEY JR, KALVIN W. K YIM, MICHAEL C. HUBERTY
Format Patent
LanguageEnglish
Published 13.08.1998
Edition6
Subjects
CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES
DISINFECTION, STERILISATION, OR DEODORISATION OF AIR
HUMAN NECESSITIES
HYGIENE
MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES
MEDICAL OR VETERINARY SCIENCE
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A composition is disclosed comprising a pharmaceutically acceptable admixture of an osteogenic protein; a porous particulate polymer matrix; an osteogenic protein-sequestering amount of blood clot; and a calcium sulfate hemihydrate-containing substance. Also disclosed are formulations of bone morphogenetic proteins with improved solubility and/or stability characteristics.
Bibliography:Application Number: AU19940079537