Melanoma associated antigen (hmw-maa) defined by a monoclonal antibody

An epitope of high molecular weight melanoma associated antigen (HMW-MAA) displayed on the surface of human cells but not cells from Macaca fascicularis is described, said epitope a) having the ability of being specifically blocked by and specifically block a binding structure which recognizes HMW-M...

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Bibliographic Details
Main Authors LENNART G. OHLSSON, M. JESPER TORDSSON, THOMAS N. BRODIN
Format Patent
LanguageEnglish
Published 19.03.2001
Edition7
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:An epitope of high molecular weight melanoma associated antigen (HMW-MAA) displayed on the surface of human cells but not cells from Macaca fascicularis is described, said epitope a) having the ability of being specifically blocked by and specifically block a binding structure which recognizes HMW-MAA, b) being displayed on the surface of human cells but not cells from Macaca fascicularis, and c) having a normal tissue distribution pattern which is more restricted than that of other known epitopes of HMW-MAA. There is also described a binding structure and antibodies recognizing target structures of said antigen, pharmaceutical compositions and vaccines as well as methods of using said epitopes and antibodies in diagnostic and therapeutic methods related to human malignant diseases.
Bibliography:Application Number: AU20000068837