Method for coupling molecules
A method of linking a first molecule M -NH2 with a second molecule M -OH comprising reaction of a compound of the formula (I): M -NH-CO-A-CO-SR wherein M is the residue of a molecule bearing an amino group, A is an alkylene or arylene group, R is alkyl or aryl, with a compound of formula (II), M is...
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| Main Authors | , |
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| Format | Patent |
| Language | English |
| Published |
26.03.2001
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| Edition | 7 |
| Subjects | |
| Online Access | Get full text |
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| Abstract | A method of linking a first molecule M -NH2 with a second molecule M -OH comprising reaction of a compound of the formula (I): M -NH-CO-A-CO-SR wherein M is the residue of a molecule bearing an amino group, A is an alkylene or arylene group, R is alkyl or aryl, with a compound of formula (II), M is the residue of a molecule bearing a hydroxy group wherein B is a linker, D is C1-4 alkylene group or C3-12 arylene group, R is hydrogen or a thiol protecting group. In addition, this invention relates to conjugate products of the coupling reaction, reagents for modifying M -NH2 and M -OH, and kits comprising these reagents. |
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| AbstractList | A method of linking a first molecule M -NH2 with a second molecule M -OH comprising reaction of a compound of the formula (I): M -NH-CO-A-CO-SR wherein M is the residue of a molecule bearing an amino group, A is an alkylene or arylene group, R is alkyl or aryl, with a compound of formula (II), M is the residue of a molecule bearing a hydroxy group wherein B is a linker, D is C1-4 alkylene group or C3-12 arylene group, R is hydrogen or a thiol protecting group. In addition, this invention relates to conjugate products of the coupling reaction, reagents for modifying M -NH2 and M -OH, and kits comprising these reagents. |
| Author | DMITRY STETSENKO MICHAEL JOHN GAIT |
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| Snippet | A method of linking a first molecule M -NH2 with a second molecule M -OH comprising reaction of a compound of the formula (I): M -NH-CO-A-CO-SR wherein M is... |
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| Title | Method for coupling molecules |
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