Method for coupling molecules

A method of linking a first molecule M -NH2 with a second molecule M -OH comprising reaction of a compound of the formula (I): M -NH-CO-A-CO-SR wherein M is the residue of a molecule bearing an amino group, A is an alkylene or arylene group, R is alkyl or aryl, with a compound of formula (II), M is...

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Bibliographic Details
Main Authors DMITRY STETSENKO, MICHAEL JOHN GAIT
Format Patent
LanguageEnglish
Published 26.03.2001
Edition7
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A method of linking a first molecule M -NH2 with a second molecule M -OH comprising reaction of a compound of the formula (I): M -NH-CO-A-CO-SR wherein M is the residue of a molecule bearing an amino group, A is an alkylene or arylene group, R is alkyl or aryl, with a compound of formula (II), M is the residue of a molecule bearing a hydroxy group wherein B is a linker, D is C1-4 alkylene group or C3-12 arylene group, R is hydrogen or a thiol protecting group. In addition, this invention relates to conjugate products of the coupling reaction, reagents for modifying M -NH2 and M -OH, and kits comprising these reagents.
Bibliography:Application Number: AU20000068539