Chrysospermins, active peptides from apiocrea chrysosperma having a pharmacological effect, a process for their preparation and the use thereof

The invention relates to the peptide drugs chrysospermines of the formula I in which x and y denote, independently of one another, Aib or Iva, which are synthesised by the fungus Apiocrea chrysosperma during fermentation and accumulate in the culture broth, to a preparation process, to the use of th...

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Bibliographic Details
Main Authors UDO GRAFE, BRIGITTE SCHLEGEL, WOLFGANG SCHADE, JORG METZGER, WOLFGANG IHN, KLAUSJURGEN DORNBERGER, WERNER FRIEDRICH FLECK
Format Patent
LanguageEnglish
Published 01.02.1996
Edition5
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES USING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:The invention relates to the peptide drugs chrysospermines of the formula I in which x and y denote, independently of one another, Aib or Iva, which are synthesised by the fungus Apiocrea chrysosperma during fermentation and accumulate in the culture broth, to a preparation process, to the use of the chrysospermines as pharmacological agents, in particular as agent against bacteria, fungi and/or nematodes and for the treatment of rejection reactions to organ transplants and of tumours, and to the microorganism Apiocrea chrysosperma DSM 7444.
Bibliography:Application Number: AU19940055226