Receptor directed-toxin conjugates

The invention relates to a targeted toxin molecule comprising a toxin and a proteinaceaous molecule with binding activity for a receptor on the surface of a target cell, whereby the proteinaceous molecule is the ligand on a functional derivative or fragment thereof and the toxin has a molecular weig...

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Bibliographic Details
Main Authors EBO SYBREN BOS, HERMANUS ANTONIUS MARIA VERHEUL
Format Patent
LanguageEnglish
Published 30.03.1995
Edition5
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention relates to a targeted toxin molecule comprising a toxin and a proteinaceaous molecule with binding activity for a receptor on the surface of a target cell, whereby the proteinaceous molecule is the ligand on a functional derivative or fragment thereof and the toxin has a molecular weight of no more than 1500 D. More specifically the ligand is IL-2, or preferably only its binding domain. The toxin may be any small toxin, for instance calicheamycin, verrucarin etc.. The toxin molecules according to the invention localize faster and are less immunogenic.
Bibliography:Application Number: AU19910080606