Nucleotide sequence coding for an outer membrane protein from meisseria meningitidis and use of said protein in vaccine preparations

The present invention is concerned with a method for the isolation of a nucleotide sequence which codes for a protein having a molecular weight of about 64 000 daltons, which is located on the outer membrane of N. meningitidis, as well as with the recombinant DNA obtained therefrom, which is used fo...

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Main Authors LIDIA INES NOVOA PEREZ, GERERDO GUILLEN NIETO, JULIO RAUL FERNANDEZ MASO, SILIAN CRUZ LEON, MANUEL SELMAN HOUSSEIN SOSA, EDELGIS COUZEAU RODRIGUEZ, BEATRIZ TAMARGO SANTOS, VIVIAN MORERA CORDOVA, EVELIN CABALLERO MENENDEZ, SONIA GONZALEZ BLANCO, ANABEL ALVAREZ ACOSTA, ALEXIS MUSACCHIO LASA, RICARDO SILVA RODRIGUEZ, JUAN MORALES GRILLO, JESUS AUGUSTO DEL VALLE ROSALES, LUIS SATURNINO HERRERA MARTINEZ
Format Patent
LanguageEnglish
Published 16.03.1995
Edition5
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES USING MICROORGANISMS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:The present invention is concerned with a method for the isolation of a nucleotide sequence which codes for a protein having a molecular weight of about 64 000 daltons, which is located on the outer membrane of N. meningitidis, as well as with the recombinant DNA obtained therefrom, which is used for the transformation of a host microorganism. The technical object pursued with the invention is the identification of a nucleotide sequence coding for a highly conserved and common protein for the majority of pathogenic Neisseria strains, the production of this protein with a high level of purity and in commercially useful amounts using the recombinant way, so that it can be used in diagnostic methods and vaccine preparations with a broad immunoprotection spectrum.
Bibliography:Application Number: AU19910083683