Bicyclic antagonists selective for the alphavbeta3 integrin

• Main Authors: KENNETH LEWIS KEES, JOHN YARDLEY, DIANE BARBARA HAUZE, ARIE ZASK, RICHARD DALE COGHLAN
• Format: Patent
• Language: English
• Published: 13.02.2001
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

This invention provides novel bicyclic compounds of Formula (I):wherein u, v, m, Y, G, A-B, R1, R1a, R2, R4, R5, R5a, and R5b are defined in the specification which compounds exhibit activity as inhibitors of bone resorption and compounds of Formula (II)wherein u, v, m, Y, G, D, A-B, R1, R1a, R2, R3...