Bicyclic antagonists selective for the alphavbeta3 integrin

This invention provides novel bicyclic compounds of Formula (I):wherein u, v, m, Y, G, A-B, R1, R1a, R2, R4, R5, R5a, and R5b are defined in the specification which compounds exhibit activity as inhibitors of bone resorption and compounds of Formula (II)wherein u, v, m, Y, G, D, A-B, R1, R1a, R2, R3...

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Bibliographic Details
Main Authors KENNETH LEWIS KEES, JOHN YARDLEY, DIANE BARBARA HAUZE, ARIE ZASK, RICHARD DALE COGHLAN
Format Patent
LanguageEnglish
Published 13.02.2001
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention provides novel bicyclic compounds of Formula (I):wherein u, v, m, Y, G, A-B, R1, R1a, R2, R4, R5, R5a, and R5b are defined in the specification which compounds exhibit activity as inhibitors of bone resorption and compounds of Formula (II)wherein u, v, m, Y, G, D, A-B, R1, R1a, R2, R3, R4, R5, R5a, and R5b are defined in the specification which compounds exhibit activity as inhibitors of bone resorption.
Bibliography:Application Number: AU20000063602