PHENOTHIAZINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

• Main Authors: BERNARD PLAU, CLAUDE GUYON, GERARD TAURAND, CLAUDE GARRET
• Format: Patent
• Language: English
• Published: 05.03.1992
• Edition: 5
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

New phenothiazine derivatives of general formula (I) in which Y is hydrogen or halogen, R1 and R2, which are identical or different, denote alkyl, cycloalkylalkyl, hydroxyalkyl or acetyloxyalkyl radicals or together with nitrogen atom to which they are attached form a saturated or partially unsaturated heterocyclic ring containing 4 to 7 chain links and optionally substituted and either X is oxygen, sulphur or N-R4, R is cycloalkyl, phenyl or -CH2R3, R3 is H, C1-5 alkyl, alkenyl or C2-4 alkynyl, C3-6 cycloalkyl, phenyl, substituted phenyl or heterocyclyl, R4 is H or -CN, with the exception that X denotes oxygen if simultaneously R3 is H or alkyl, R1 and R2 are alkyl or NR1R2 forms an unsubstituted heterocyclic ring and Y is H; or X is N-R4 and R4 forms with R and the neighbouring atoms an imidazolinyl or optionally substituted imidazolyl or hexahydrobenzimidazolyl radical, in their isomeric forms and mixtures thereof, their addition salts with acids, their preparation and the pharmaceutical compositions containing them. These products are particularly advantageous as analgesics and diuretics.