DERIVATIVES OF 16,17-DIHYDROXYPREGNANE
The invention relates to novel DELTA -16 alpha ,17-dihydroxy-pregnane-16,17-cyclic aldehyde acetal and -cyclic ketone ketal derivatives of general formula (I), wherein A stands for hydrogen or hydroxyl group; X stands for hydrogen or halogen with the proviso that if A is hydrogen, then X also means...
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Main Authors | , , , , , , , , , , , , |
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Format | Patent |
Language | English |
Published |
05.12.1991
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Edition | 5 |
Subjects | |
Online Access | Get full text |
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Summary: | The invention relates to novel DELTA -16 alpha ,17-dihydroxy-pregnane-16,17-cyclic aldehyde acetal and -cyclic ketone ketal derivatives of general formula (I), wherein A stands for hydrogen or hydroxyl group; X stands for hydrogen or halogen with the proviso that if A is hydrogen, then X also means hydrogen; R stands for hydrogen,benzoyl or C1<->8alkanoyl group; R and R , which are the same or different, stand for hydrogen or a C1<->4alkyl group; or one of R and R is hydrogen and the other is phenyl group; or R and R together form a C4<->5alkylene group; --- means a single or double bond between two adjacent carbon atoms, as well as pharmaceutical compositions containing these compounds and a process for their preparation. The compounds of general formula (I) possess a very strong antiinflammatory effect and only week harmful side effect. Thus, they can be used as active ingredients of antiinflammatory pharmaceutical compositions being useful in the therapy. |
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Bibliography: | Application Number: AU19900050798 |