CONDENSED QUINOLINIUM AND ISOQUINOLINIUM DERIVATIVES

The new compounds of the general Formula I I (wherein R1 stands for C1-4 alkyl or aralkyl; and R2 represents hydroxy; or R1 and R2 together form a valency bond; R3 is hydrogen, C1-4 alkyl, C1-4 alkoxy, phenyl, amino, alkylthio or a group of the Formula -NR7R8 in which R7 and R8 may be the same or di...

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Main Authors LASZLO PALLOS, ZSUZSA JUHASZ, ENIKO SZIRT, GABOR GIGLER, ISTVAN GYERTYAN, MARIA HEGEDUS, PAL BENKO, ANDRAS MESSMER, LUJZA PETOCZ, GYORGY HAJOS
Format Patent
LanguageEnglish
Published 21.03.1991
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The new compounds of the general Formula I I (wherein R1 stands for C1-4 alkyl or aralkyl; and R2 represents hydroxy; or R1 and R2 together form a valency bond; R3 is hydrogen, C1-4 alkyl, C1-4 alkoxy, phenyl, amino, alkylthio or a group of the Formula -NR7R8 in which R7 and R8 may be the same or different and stand for hydrogen, C1-4 alkyl, phenyl-C1-4 alkyl, hydroxy-C1-4 alkyl or di-(C1-4 alkyl)-amino-C1-4 alkyl or together with the nitrogen atom they are attached to form a 6-membered heterocyclic ring which may optionally contain a further nitrogen, oxygen or sulfur atom; or R2 and R3 together form an oxo (=O) or thixo (=S) group; R4 represents hydrogen, C1-4 alkyl or phenyl which may optionally bear one or two halogen or nitro substituent(s); Z is a group of the Formula (a) or (b) and A- represents an anion) and isomers thereof possess useful local anaesthetic, antidepressant, tranquillo-sedative and smooth muscle relaxant properties accompanied by a weaker analgesic effect and are useful in therapy.
Bibliography:Application Number: AU19880023345