INFECTIOUS RECOMBINANT VIRUS VACCINES FOR FELINE LEUKEMIA

Infectious recombinant viruses that contain a chimeric FeLV envelope gene and are useful as feline leukemia vaccines are described. The viruses are made by transfecting susceptible mammalian cells with DNA of the virus and an insertion vector that includes a chimeric gene comprising a promoter that...

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Bibliographic Details
Main Authors JACK HENRY NUNBERG, JAMES HARRIS GILBERT
Format Patent
LanguageEnglish
Published 07.03.1991
Edition5
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES USING MICROORGANISMS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
TESTING
VINEGAR
WINE
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Summary:Infectious recombinant viruses that contain a chimeric FeLV envelope gene and are useful as feline leukemia vaccines are described. The viruses are made by transfecting susceptible mammalian cells with DNA of the virus and an insertion vector that includes a chimeric gene comprising a promoter that is active in the cells, a translation start codon, and a DNA sequence that encodes an FeLV envelope protein and is under the control of the promoter. Vaccines composed of such infectious recombinant viruses and a parenteral vehicle or of inactivated preparation of cells or cell fractions which had been infected with said recombinant viruses are also described.
Bibliography:Application Number: AU19860062416