HUMAN MONOCLONAL ANTIBODIES TO HIV-1ÕMN? GP 120

An antibody capable of neutralizing the MN prototype of HIV or an MN variant virus thereof, wherein an amino acid sequence within the principal neutralizing domain of the MN prototype comprises the sub-sequence, at positions A -A of the principal neutralizing domain, of amino acid residues K-R-K-R-I...

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Bibliographic Details
Main Authors JAMES R. RUSCHE, SANDRA SILVER, HELEN F. CARSON, CHARLES F. SCOTT JR, MARY E. WHITE-SCHARF
Format Patent
LanguageEnglish
Published 07.01.1991
Edition5
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES USING MICROORGANISMS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
TESTING
VINEGAR
WINE
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Summary:An antibody capable of neutralizing the MN prototype of HIV or an MN variant virus thereof, wherein an amino acid sequence within the principal neutralizing domain of the MN prototype comprises the sub-sequence, at positions A -A of the principal neutralizing domain, of amino acid residues K-R-K-R-I-H-I-G-P-G-R-A-F-Y-T-T-K, and the corresponding amino acid sub-sequence of the MN variant includes a completely homologous sequence at the I-G-P-G-R residues at positions A -A11 and at least 36 % homology over the remaining residues of the MN prototype sub-sequence.
Bibliography:Application Number: AU19900060366