4ALPHA-ARYL-TRANS-DECAHYDROISOQUINOLINES

1436377 Isoquinoline derivatives E I DU PONT DE NEMOURS & CO 19 July 1973 [20 July 1972 1 June 1973] 39387/75 Divided out of 1436376 Heading C2C The invention comprises compounds of the formulµ where R1 is H, C 1 -C 6 alkyl, benzyl, phenethyl or cycloalkylmethyl of the formula -CH 2 CH(CH 2 ) n...

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Bibliographic Details
Main Authors WILLIAM CHARLES RIPKA, DAVID ROSS BRITTELLI
Format Patent
LanguageEnglish
Published 23.01.1975
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:1436377 Isoquinoline derivatives E I DU PONT DE NEMOURS & CO 19 July 1973 [20 July 1972 1 June 1973] 39387/75 Divided out of 1436376 Heading C2C The invention comprises compounds of the formulµ where R1 is H, C 1 -C 6 alkyl, benzyl, phenethyl or cycloalkylmethyl of the formula -CH 2 CH(CH 2 ) n where n is 2-5, R5 is or Ar1 is a group of the formula where R7 is H or methoxy, R8 is methoxy or two of R7 or of R8 on adjacent carbons may together form a methylenedioxy group with the proviso that R1 is not H in compounds of Formulµ II or III. Compounds of Formula I where R1 is H are prepared by treating a compound of the formula with R6OH and HCl where R6 is C 1 -C 4 alkyl. The compounds may be alkylated and subsequently reduced to give compounds of Formula II or epoxidized to give compounds of Formula III.
Bibliography:Application Number: AU19730058207