Macrocyclic inhibitors of matrix metalloproteinases and tnfalpha secretion

Macrocyclic compounds of formula (I) are potent inhibitors of matrix metalloproteinase and are useful in the treatment of diseases in which matrix metalloproteinase play a role. Also disclosed are matrix metalloproteinase inhibiting compositions and a method of inhibiting matrix metalloproteinase in...

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Bibliographic Details
Main Authors LIANHONG XU, DOUGLAS H STEINMAN, MICHAEL R MICHAELIDES, GEORGE S SHEPPARD, STEVEN K. DAVIDSEN, YAN GUO, JAMES H. HOLMS, JAMES B. SIUMMERS, ALAN SCOTT FLORJANCIC
Format Patent
LanguageEnglish
Published 03.08.1998
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Macrocyclic compounds of formula (I) are potent inhibitors of matrix metalloproteinase and are useful in the treatment of diseases in which matrix metalloproteinase play a role. Also disclosed are matrix metalloproteinase inhibiting compositions and a method of inhibiting matrix metalloproteinase in a mammal.
Bibliography:Application Number: AU19980058155