N- 2-DIHYDROXYPHOSPHINYL -3- SUBSTITUTED PHENYL PROPIONYL -LEUCINE

• Main Authors: ROGER WRIGGLESWORTH, SAMUEL WILKINSON, GEORGE WILLIAM HARDY
• Format: Patent
• Language: English
• Published: 23.01.1986
• Edition: 4
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

Compounds of the general formulawheren Ph is a phenyl group which is optionally substituted by one or more substituents selected from halo (i.e. fluoro, chloro, bromo or iodo), C1-4alkyl, amino, C1-4alkylamino, di-C1-4alkylamino, nitro, sulphonyl, aminosulphonyl, trihalomethyl, carboxy, C1-4alkoxycarbonyl, amido, C1-4alky(amido C1-4alkoxy, C2-4alkenyl, cyano, aminomethyl or methylsulphonyl; R' und Rb, which may be the same or different, each represents a hydrogen or alkali metal (eg. sodium or lithium) atom or a C1-4 (eg. ethyl) group; m is 0 or 1;Y is a group of formula:or a group of formula:whereR' is hydrogen or methyl;R2 is alkyl of 1 to 3 carbon atoms or is methylthiomethyl; andZ is -OR3 or -NR4Rs where R3, R4 and R5 are each hydrogen or alkyl of 1 to 4 carbon atoms (ie. methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, or t-butyl) and R3 can further be phenylalkyl having 1 to 3 carbon atoms in the alkylene moiety thereof, or phenyl; and basic salts thereof. These compounds have an advantageous enkephalinase inhibitor activity which renders the compounds useful in medical therapy, eg. to prolong and/or potentiate in a mammal, the effects of endogenous or exogenous enkephalins. The latter includes synthetic enkephalin analogues.