CLAVULANIC ACID DERIVATIVES

Clavulanic acid derivs. of formula (I) and their salts are new: In (I) R is a monoacylamino or dicarboximido gp; R1 is opt. esterified COOH). Cpds. (I) are (i) beta-lactamase inhibitors useful for protecting penicillin- and cephalosporin-type antibiotics from attack by beta-lactamasses produced by G...

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Bibliographic Details
Main Authors A.P. TONGE, C.E. NEWALL, P.C. CHERRY
Format Patent
LanguageEnglish
Published 03.09.1981
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Clavulanic acid derivs. of formula (I) and their salts are new: In (I) R is a monoacylamino or dicarboximido gp; R1 is opt. esterified COOH). Cpds. (I) are (i) beta-lactamase inhibitors useful for protecting penicillin- and cephalosporin-type antibiotics from attack by beta-lactamasses produced by Gram-positive and negative bacteria, and (ii) antibiotics active against Gram-positive and -negative bacteria, including lactamase-producing strains. A typical cpd. is Na (3R, 5R, Z)-2-(2-acetamidoethylidene)-clavam-3-carboxylate. In an example, this is prepd. from (3R, 5R, Z)-2-(2-amino-ethylidene)-clavam-3-carboxylic acid and acetic anhydride.
Bibliography:Application Number: AU19770030021