DERIVATIVES OF 16,17-DIHYDROXYPREGNANE

The invention relates to novel DELTA -16 alpha ,17-dihydroxy-pregnane-16,17-cyclic aldehyde acetal and -cyclic ketone ketal derivatives of general formula (I), wherein A stands for hydrogen or hydroxyl group; X stands for hydrogen or halogen with the proviso that if A is hydrogen, then X also means...

Full description

Saved in:
Bibliographic Details
Main Authors LASZLO SZPORNY, ARPAD KIRALY, SANDOR HOLLY, KRISZTINA SZEKELY, ANNA BOOR, JANOS CSORGEI, CSABA MOLNAR, GYORGY HAJOS, JOZSEF SZUNYOG, JOZSEF TOTH, GYORGY FEKETE, BULCSU HERENYI, LILLA FORGACS
Format Patent
LanguageEnglish
Published 20.09.1990
Edition5
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
Online AccessGet full text

Cover

More Information
Summary:The invention relates to novel DELTA -16 alpha ,17-dihydroxy-pregnane-16,17-cyclic aldehyde acetal and -cyclic ketone ketal derivatives of general formula (I), wherein A stands for hydrogen or hydroxyl group; X stands for hydrogen or halogen with the proviso that if A is hydrogen, then X also means hydrogen; R stands for hydrogen,benzoyl or C1<->8alkanoyl group; R and R , which are the same or different, stand for hydrogen or a C1<->4alkyl group; or one of R and R is hydrogen and the other is phenyl group; or R and R together form a C4<->5alkylene group; --- means a single or double bond between two adjacent carbon atoms, as well as pharmaceutical compositions containing these compounds and a process for their preparation. The compounds of general formula (I) possess a very strong antiinflammatory effect and only week harmful side effect. Thus, they can be used as active ingredients of antiinflammatory pharmaceutical compositions being useful in the therapy.
Bibliography:Application Number: AU19900050798