5-O-desosaminylerythronolide a derivative

Object: to provide a novel macrolide antibiotic having a potent antibacterial activity. Constitution: a tricyclic carbamate derivative of a 3-oxo-6-methoxy-substituted 5-O-desosaminylerythronolide A derivative represented by general fomula (I), and a pharmaceutically acceptable acid addition salt th...

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Bibliographic Details
Main Authors YOKO MISAWA, SHIGEO MORIMOTO, KATSUO HATAYAMA, TOSHIFUMI ASAKA, MASATO KASHIMURA
Format Patent
LanguageEnglish
Published 18.11.1993
Edition5
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SUGARS
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Summary:Object: to provide a novel macrolide antibiotic having a potent antibacterial activity. Constitution: a tricyclic carbamate derivative of a 3-oxo-6-methoxy-substituted 5-O-desosaminylerythronolide A derivative represented by general fomula (I), and a pharmaceutically acceptable acid addition salt thereof. In formula (I), -A-- represents -N(R )- (wherein R represents hydrogen or C1-C3 alkyl) or -N=; and R and R represent each C1-C3 alkyl. An intermediate, represented by general formula (II), useful for producing the 3-oxo-substituted 5-O-desosaminylerythronolide A derivative, wherein R represents acetyl or propionyl.
Bibliography:Application Number: AU19930040223