5-DEAZA-5,7-DISUBSTITUTED-AMINOPTERIN ANALOGUES

This invention relates to the compound having structure (I), wherein R5 is a hydrogen atom, a lower alkyl group of 1-4 carbons or a phenyl group, R7 is a lower alkyl group of 1-4 carbons or a phenyl group, and R10 is a hydrogen atom, a methyl group or an ethyl group. The invention also relates to me...

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Bibliographic Details
Main Authors KYOICHI A. WATANABE, TSANN-LONG SU, JAI-TUNG HUANG
Format Patent
LanguageEnglish
Published 23.01.1990
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention relates to the compound having structure (I), wherein R5 is a hydrogen atom, a lower alkyl group of 1-4 carbons or a phenyl group, R7 is a lower alkyl group of 1-4 carbons or a phenyl group, and R10 is a hydrogen atom, a methyl group or an ethyl group. The invention also relates to methods and intermediates involed in synthesizing the compound, pharmaceutical composition of the compound and use of the compound to kill tumor cells and treat subjects.
Bibliography:Application Number: AU19890038431