PEPTIDES

A method of preparing a peptide useful as a pharmaceutical product, characterized by the operations of preparing an N alpha-protected cistern amino acid ester and a chloromethylated resin, deprotecting said cis-amino-acid amino acid and stagingly coupling N alpha-protected amino acids to said cystei...

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Bibliographic Details
Main Authors MARVIN ROSS BROWN, JEAN EDOUARD FREDERIC RIVIER, WYLIE WALKER VALE , JR
Format Patent
LanguageEnglish
Published 27.09.1979
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A method of preparing a peptide useful as a pharmaceutical product, characterized by the operations of preparing an N alpha-protected cistern amino acid ester and a chloromethylated resin, deprotecting said cis-amino-acid amino acid and stagingly coupling N alpha-protected amino acids to said cysteine to form a peptide-bound resin having the structure: cysteine-R1-phenylalanine-phenylalanine-R2-lysine-R3-phenylalanine-R4-R5-cysteine, wherein R1 is selected from the group consisting of asparagine and desR1; R2 is selected from the group consisting of tryptophan and D-tryptophan; R3 is selected from the group consisting of phenylalanine and threonine; R4 is selected from the group consisting of threonine and desR4; and R5 is selected from the group consisting of serine, phenylalanine, and desR5 as long as at least one of R1, R4, and R5 is deleted. (Machine-translation by Google Translate, not legally binding)
Bibliography:Application Number: AU19780034307