Novel (n)-alkoxyadenine derivatives acting as cytokine inhibitors

The present invention relates to novel N,9-disubstituted adenine derivatives and novel aristeromycin analogues which are further substituted at the adenine 2-position, and which have a hydroxymethyl group, or an ester or ester isostere at a position corresponding to the ribose 4-position, and pharma...

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Bibliographic Details
Main Authors DAVID R. VARLEY, UFFE BANG OLSEN, LARS KNUTSEN, STANLEY M. ROBERTS, ANDREW NEIL BOWLER
Format Patent
LanguageEnglish
Published 02.02.1998
Edition6
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:The present invention relates to novel N,9-disubstituted adenine derivatives and novel aristeromycin analogues which are further substituted at the adenine 2-position, and which have a hydroxymethyl group, or an ester or ester isostere at a position corresponding to the ribose 4-position, and pharmaceutically acceptable addition salts thereof. The compounds act as cytokine inhibitors. Also covered are processes for preparation of the above derivatives and their pharmaceutical compositions as well as methods for using the compounds and compositions as drugs for the treatment of disorders involving cytokines in humans.
Bibliography:Application Number: AU19970032550