Integrin expression inhibitors

• Main Authors: TARO SEMBA, NORIHIRO UEDA, KEIKO TAKAHASHI, YASUHIRO FUNAHASHI, TADASHI OKABE, YUJI YAMAMOTO, TORU HANEDA, TAKASHI OWA, KAZUMASA NARA, NAOKO HATA, SHINICHI HAMAOKA, TOSHIAKI WAKABAYASHI, AKIHIKO TSURUOKA, JUN-ICHI KAMATA
• Format: Patent
• Language: English
• Published: 14.08.2001
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides an integrin expression inhibitor, and an agent for treating arterial sclerosis, psoriasis, cancer, retinal angiogenesis, diabetic retinopathy or inflammatory diseases, an anticoagulant, or a cancer metastasis suppressor on the basis of an integrin inhibitory action. Namely, it provides an integrin expression inhibitor comprising, as an active ingredient, a sulfonamide compound represented by the following formula (I), a pharmacologically acceptable salt thereof or a hydrate of them. In the formula, B means a C6-C10 aryl ring or 6- to 10-membered heteroaryl ring which may have a substituent and in which a part of the ring may be saturated; K means a single bond, -CH=CH- or - (CR R )m- (wherein R and R are the same as or different from each other and each means hydrogen atom or a C1-C4 alkyl group; and m means an integer of 1 or 2); R means hydrogen atom or a C1-C6 alkyl group; Z means a single bond or -CO-NH-; and R means a C6-C10 aryl ring or 6- to 10-membered heteroaryl ring which may have a substituent and in which a part of the ring may be saturated, respectively.